It is wise to remember none of us knows what is really going on. I have met many who would deny this, many who would agree publicly but refuse the idea inside. It could be a scary thought, but I find it liberating. The practice of letting go starts with collecting things and giving up those things comes with identifying why they were important and loosening that grip. Doing that releases such tension that there is a sudden relaxation, a freeing of energy better used for other things like life.
The next step of letting go is to find out what we think is a fact, real, the truth and to let go of that. I like to think of those who changed their minds and of Lewis Carroll "Sometimes I have believed as many a six impossible things before breakfast." Because so often what has been believed has turned out to be wrong. I think when we get to this step is when life begins to be really fun. It is just not necessary to worry anymore.
Such a simple and fundamental quote from the canon as "Those who take refuge in the Buddha, Dhamma, Sangha fear not," must be interpreted personally and individually for each moment but can simply mean - "yes, we know this is impermanent and that is fine." Either you know something is not going to last and accept that and enjoy it anyway, or you know something is not going to last and are so glad that is so. It is the nature of life.
Most people don't realize that they usually believe six impossible things before breakfast. They think those impossible things are real.